ISSN 2375-0731
African Journal of Pig Farming ISSN: 2375-0731 Vol. 11 (3), pp. 001-010, March, 2023. © International Scholars Journals
Full Length Research Paper
In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses
Marina A. Padilla1,2, Isabela C. Simoni1*, Verônica Moreira H. Hoe1, Maria Judite B. Fernandes1, Clarice W. Arns2, Juliana R. Brito3 and João Henrique G. Lago4
1Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biológico, Av. Cons. Rodrigues Alves, 1252, CEP 04014-900, São Paulo, SP, Brasil.
2Laboratório de Virologia Animal, Universidade Estadual de Campinas, Campinas, SP, Brasil.
3Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, São Paulo, Brazil.
4Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, São Paulo, Brazil.
Accepted 16 January, 2023
Abstract
The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine herpesviruses (SuHV-1). The results showed that all plant extracts: Banisteriopsis variabilis, Byrsonima intermedia, Campomanesia xanthocarpa, Erythroxilum deciduum, Lacistema hasslerianum, Ocotea pulchella, Stryphodendron adstringens and Xylopia aromatica presented antiviral activity against at least one herpesvirus. Furthermore, it was observed a direct anti-herpes effect of extracts from B. variabilis and B. intermedia in non-toxic concentrations against all herpesviruses. B. intermedia crude aqueous extract showed the most promising results with selective index values of the 41.76 ± 0.04; 4.12 ± 0.1 and 193.97 ± 0.09 respectively against HSV-1, EqHV-1 and SuHV-1. Due to this, B. intermedia extract was also analyzed by HPLC/MS allowing for the identification of gallic acid and quercetin as main compounds.
Key words: Brazilian savanna, Cerrado, Byrsonima intermedia, antiviral, herpesvirus, gallic acid, quercetin.