International Journal of Urology and Nephrology

International Journal of Urology and Nephrology ISSN 2091-1254 Vol. 6 (3), pp. 001-006, March, 2018. © International Scholars Journals

Full Length Research Paper

Penta-and hexapeptide sharing between HPV16 and Homo sapiens proteomes

Darja Kanduc

Department of Biochemistry and Molecular Biology, University of Bari, Italy. E-mail:, Tel: +39 080 544 3321. Fax: +39 080 544 3321.

Accepted 21 August, 2017


The primary sequence of the HPV16 proteome was analyzed for penta- and hexa- peptide sequences shared with human proteins. The following data were obtained: 1) HPV16 and Homo sapiens proteomes share thousands of identical peptide motifs; 2) the overlaps are inter-dispersed among human proteins involved in fundamental housekeeping functions as well as crucial processes such as cell growth, differentiation and neurosensory regulation. The data are discussed in relationship to the potential cross-reactivity risk of an HPV16 vaccine.

Key words: Similarity analysis, sequence-sequence peptide matching, viral versus human proteome over-lapping, vaccine-related cross-reactions.