International Journal of Obstetrics and Gynecology

International Journal of Obstetrics and Gynecology ISSN 2326-7234 Vol. 6 (5), pp. 223-226, May, 2018. © International Scholars Journals

Review

Granulomatous inflammation in lymph nodes draining cancer: A coincidence or a significant association

Ali Damor1*, Akbar Khan2 and Bansi Ram2

1Department of Infectious disease, Faculty of Medicine, Kannur University, Kannur, Kerala, India

 2Department of Medical Oncology, Faculty of Medicine, University of Mysore, Karnataka, India.

*Corresponding author. E-mail: ali_damor@yahoo.com.

Accepted 02 March, 2017

Abstract

Granulomatous inflammation is considered to be an immune mechanism against infections or certain non-neoplastic conditions. Rarely granuloma formation may be noted in neoplastic disorders also. However a granulomatous response in the lymph nodes draining cancers is unusual. Such granulomas may sometimes show tumour cells in their centre. The exact cause of this phenomenon is not known but an immunologic reaction to tumour antigens has been suggested. A close scrutiny of such granuloma is necessary to avoid under diagnosis of a metastatic disease. Subtle morphological fea-tures which may be helpful in differentiating a co-existing infection or tumour induced granuloma need to be addressed. Moreover the biologic significance of such a granulomatous response in inducing tu-mour remission or in shielding tumour cells from host lymphocytes also requires further investigation.

Key words: Granuloma, cancer, metastasis.