International Journal of Medical Sociology and Anthropology

International Journal of Medical Sociology and Anthropology Vol. 9 (9), pp. 001-004, September, 2020. © International Scholars Journals

Full Length Research Paper

Hepatoprotective potentials of Butea monosperma stem bark extract against carbon tetrachloride induced hepatotoxicity in albino rats

Prashant Tiwari1*, Kuldeep Kumar2, Rajnikant Panik3, Alok Pandey4, Ashish Pandey4 and Pratap Kumar Sahu4

1Pinnacle Biomedical Research Institute Bhopal, Madhya Pradesh, India.

2Smt. Vidyawati Collage of Pharmacy, Jhansi Uttar Pradesh, India.

3Government Girls Polytechnic, Baron Bazar, Raipur, Chhattisgarh, India.

4Raipur Institute of Technology, Raipur Chhattisgarh, India.

5Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, Bhubaneswar, India.

Accepted 13 June, 2020

Abstract

Carbon tetrachloride (CCl4) pharmacological tool was used to produce liver damage in rats. Silymarin (100 mg/kg) and extract of Butea monosperma (shown to be hepatoprotective substances) prevented the CCl4 induced toxicity. Hydroalcholic extract of the stem bark of B. monosperma was evaluated for its hepatoprotective. This in vitro efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 and 200 mg/kg dose) by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation while it significantly increased the reduced Glutathione levels of tissue in a dose dependant manner. The hepatoprotective activities of the extract are being comparable to standards Silymarin. The results obtained in the present study indicate that stem bark extract of B. monosperma is a potential source of natural hepatoprotective. The hepatoprotective property may be attributed to the antioxidant potential and the phytochemical constituents of the plant. The present study justifies the claim of the native practitioner that the decoction of the plant is useful in treating jaundice and find out the clinical efficacy of the B. monosperma.

Key words: Carbon tetrachloride, Butea monosperma, silymarin, alanine amino transferase, glutathione, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, hepatoprotection.