International Journal of Medical Advances and Discoveries

International Journal of Medical Advances and Discovery ISSN 2756-3812 Vol. 7 (2), pp. 001-007, February, 2020. © International Scholars Journals

Full Length Research Paper

Metabolic syndrome in Japanese patients with mental retardation

Shunya Hoshino1, Kenji Yamamoto1*, Shingo Miyaji1, Yoshiro Sakai1,2, Hiroaki Yamamoto1, Masami Inui Yukawa1 and Hitoshi Miyaoka1

1Department of Psychiatry, Kitasato University School of Medicine Kitasato 1-15-1, minami-ku, Sagamihara, Kanagawa 252-0374, Japan.

2Hatano Kousei Hospital, Minamiyana 2-12-1, Hatano, Kanagawa 257-0003, Japan.

Accepted 16 October, 2019


To conduct a study on metabolic syndrome (MetS) observed in patients with mental retardation (MR) to clarify the factors associated with its prevalence and incidence. During the period from October 2006 to March 2007, for 302 cases of patients with MR who were admitted to or visited 2 support facilities for people with intellectual disabilities in Japan, we reviewed the patients’ admission records and nursing records regarding their clinical data and profiles. The prevalence of MetS in Japanese patients with MR was 29 cases among 203 males (14.3%) and 12 cases among 99 females (12.1%). There was a significant association between the distribution of the severity of MR and MetS, and regarding treatment drugs, there was a significantly large number of patients who were taking antidepressants or atypical antipsychotics in the MetS group. MetS is prevalent in patients with MR. A significant correlation was observed between MetS and the severity of MR and treatment drugs, and this seems to be an important factor when considering MetS in patients with MR.

Key words: Mental retardation, metabolic syndrome, antipsychotics, antidepressants.