International Journal of Anatomy and Physiology

International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 9 (2), pp. 001-004, February, 2020. © International Scholars Journals

Full Length Research Paper

Effect of monosodium glutamate on hematological parameters in Wistar rats

Ashaolu J. O.1*, Ukwenya V. O.1, Okonoboh A. B.2, Ghazal O. K.2, Jimoh A. A. G.3

1Department of Anatomy, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria.

2Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.

3Department of Obstetrics and Gynaecology, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.

Accepted 09 October, 2019

Abstract

Monosodium glutamate (MSG) is a food additive commonly consumed as a flavor enhancer. However, both animal models and human clinical reports have established its harmful effects. The rats in two groups (A1 and B1) were administered with 5.5 g/kg body weight (b.wt) and 2.75 g/kg b.wt of MSG for 14 and 28 days respectively each, while Groups A2 and B2 were withdrawal groups for A1 and B1 which were sacrificed 14 days post-administration. At the end of the study periods, blood samples were analyzed for hematological parameters. Test results showed significant effect (p<0.05 compared to control) on the neutrophil and lymphocyte count which are indicative of a compromised immune status and poisoning in the treated animals. Packed cell volume (PCV), hemoglobin (Hb), red blood cells (RBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values analyzed were all indicative of an anemic condition in the treated animals. These findings support that MSG despite its flavoring functions, is detrimental to health.

Key words: Monosodium glutamate, hematological parameters, neutrophil and lymphocyte count, RBC count, PCV, hemoglobin concentration, MCV, MCH, MCHC, immunity, anemia, automatic hematological assay analyzer.