International Journal of Anatomy and Physiology

International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 9 (2), pp. 001-004, February, 2020. © International Scholars Journals

Full Length Research Paper

Anti-inflammatory and anti-nociceptive effects of the methanolic extract of the stem bark of Ficus vallis-choudae delile (Moraceae)

A. Lawan1*, U. A. Katsayal2 and A. H. Yaro3

1Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria

2Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria

3Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria

Accepted 16, November 2019

Abstract

The methanolic stem bark extract of Ficus vallis-choudae was investigated for anti-inflammatory and anti-nociceptive activity. The anti- inflammatory effects were investigated using rat paw edema model, while the analgesic effects were studied using acetic acid induced writhing in mice. The results obtained revealed that the methanolic stem bark extract of F. vallis – choudae in doses of 50 and 100 mg/kg posses significant (P < 0.05) dose dependent anti-inflammatory effect and inhibit abdominal contractions caused by acetic acid in mice. The intraperitoneal LD50 in mice was found to be 470 mg/kg. The preliminary phytochemical screening revealed the presence of glycosides, flavonoids, tannins, alkaloids and saponins. The results of this study indicated the presence of biologically active substances which may be beneficial in the treatment of pain and inflammation.

Key words: Acetic acid - induced writhing, Anti-nociceptive, Anti-inflammatory, F. Vallis-choudae, Rat paw edema.