African Journal of Parasitology Research
African Journal of Parasitology Research ISSN 2756-3391 Vol. 8 (6), pp. 001-006, June, 2021. © International Scholars Journals
Full Length Research Paper
The contribution of host cells to dengue virus infectivity
Woraphol Rattanachuen, Lukkana Suksanpaisan, Nitwara Wikan and Duncan R. Smith*
Molecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Thailand.
Accepted 15 April, 2021
Dengue virus infections remain a significant worldwide public health problem, causing millions of new infections each year. Transmitted by mosquitoes of the Aedes genus, the virus is capable of replicating in a number of different cells of both mosquito and human origin, but the molecular mechanism of infection remains largely unknown. This study sought to determine if the host cell in which a virus was produced had an effect on its subsequent ability to infect other cells. The study used dengue serotype 1 and 2, propagated in both insect (C6/36) and mammalian (Hep3B liver cells) to infect both C6/36 and Hep3B cells. Results showed clearly that both serotype and host cell modulated the ability of the virus to infect cells.
Key word: Aedes, dengue, flavivirus, infection, liver.
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