African Journal of Parasitology Research

African Journal of Parasitology Research ISSN 2756-3391 Vol. 8 (1), pp. 001-004, January, 2021. © International Scholars Journals

Full Length Research Paper

Carvacrol and thymol components inhibiting Pseudomonas aeruginosa adherence and biofilm formation

El abed Soumya1,2, Ibnsouda koraichi Saad1,2*, Latrache Hassan3, Zineb Ghizlane1, Mouradi Hind1 and Remmal Adnane4

1Laboratoire de Biotechnologie Microbienne, Faculté des Sciences et Techniques de Fès- Saïs, Morocco.

2Centre Universitaire Régional d’Interface, Université Sidi Mohamed Ben Abdellah –Fès, Morocco.

3Laboratoire de Valorisation et de Sécurité des Produits Agroalimentaires, Faculté des Sciences et Techniques de BéniMellal, Morocco.

4Laboratoire de Biotechnologie, Faculté des Sciences Dhar El Mehraz –Fès, Morocco.

Accepted 22 November, 2020


Pseudomonas aeruginosa has a high propensity to develop biofilms that are resistant to exogenous deleterious agents. The aim of this study was to investigate whether carvacrol and thymol can interfere with adherence phenomena as well as acting on biofilm formation. Tests of P. aeruginosa strains showed that carvacrol and thymol interferes with the starting phases of adherence as well as with P. aeruginosa biofilms. Carvacrol and thymol (2MIC) inhibition was 97±8.5 and 89±6.3% for P. aeruginosa (ATCC 27853) and 72±4.6 and 69±6.8% for P. aeruginosa (CIP A22) adherence respectively. Carvacrol (2MIC) inhibition exceeds 90% for P. aeruginosa (ATCC 27853) and P. aeruginosa (IL5) biofilm. Thymol (2MIC) inhibition is 86±2.1, 54±5.9 and 70±4.3% for P. aeruginosa (ATCC 27853) P. aeruginosa (CIP A22), P. aeruginosa (IL5), respectively.

Key words: Biofilm, adherence, carvacrol, thymol, Pseudomonas aeruginosa.