African Journal of Internal Medicine ISSN 2326-7283 Vol. 5 (6), pp. 433-439, June, 2017. © International Scholars Journals
Sclerosing angiomatoid nodular transformation of spleen: A report about a new clinical observation and literature review
1Konan Michel*, 1Binan Yves, 2Ndajustin, 1Acko Ubrich, 1Dosso Soualhio, 1Adom Hilaire, 1Toutou Toussaint
1Department of Internal Medicine and Geriatrics, University Hospital Center (UHC)-Treichville, Abidjan- Cote d’Ivoire.
2Department of Pathology Anatomy, University Hospital Center (UHC)-Cocody, Abidjan- Cote d’Ivoire.
*Corresponding author E-mail: email@example.com. Tel.: +22507533942//+22549344288.
Accepted 03 January, 2017
Sclerosing angiomatoid nodular transformation of spleen is a benign primitive vascular tumor of unknown etiology first described in 2004 by Martel et al. This condition can occur at any age with a female predominance but has been rarely described in children. The clinical signs found in our study are mainly splenomegaly and weight loss occurring in a context of chronic inflammatory syndrome and mixed microcytic anemia in a 39-year-old patient. CT and abdominal MRI used preoperatively helped the diagnosis of sclerosing angiomatoid nodular transformation of spleen (SANT) even though the radiological characteristics of splenic lesions observed were little specific. Immunohistochemistry after biopsy of the spleen helped make the diagnosis of certainty of SANT. Pathological examination of SANT reveals a splenic parenchyma replaced by well circumscribed angiomatoid nodules separated by an inflammatory fibro sclerotic stroma. Splenectomy by laparoscopic surgery with curative purpose ended all chronic inflammatory process maintained by this benign vascular lesion of spleen.
Keywords: Sclerosing angiomatoid nodular transformation of spleen, vascular injury, splenectomy, immunohistochemistry.