International Journal of Otolaryngology and Ophthalmology

International Journal of Otolaryngology and Ophthalmology ISSN 7329-1943 Vol. 2 (5), pp. 061-070, December, 2016. © International Scholars Journals

Full Length Research Paper

Synthesis of ophthalmic gels of aceclofenac to provide sustained local action in the eye

 Dhyan Raj Kapoor*, Bhagat H. Sahil, Azim J. Salman and Ram Ambani

Department of Pharmacy, Sagar Institute of Technology and Management, Barabanki, UP, India.

E-mail:  dhyan2020@yahoo.com

Accepted 10 November, 2016

Abstract 

This study deals with ophthalmic gel of aceclofenac which is potent non-steroidal antiinflammatory drugs (NSAIDs) and was formulated using polymers hydroxy propyl methyl cellulose (HPMC) (15) cps with methyl cellulose (40) cps and HPMC (15) cps with Carbopol (940). The gels (HP with MC) and (HP with CB), were sterilized and assessed for various parameters like clarity, pH, physical appearance, physical stability, viscosity and uniformity of drug content. The release rate from the aforementioned formulation within a period of 9 h were almost HP with MC batch H4 (84.66%) and for HP with CB batch C1 (80.46%); both ophthalmic gels obeyed zero order kinetics for drug release. The ocular irritation was carried out on male albino rabbits and found no redness, no inflammation and no increases tear. Both formulations in gel were found to be more stable at ambient, refrigerator and incubated temperature. The stability of the gels was evidenced by the degradation rate constant. Ophthalmic gel formulated by HP with MC and HP with CB gels proves to be viable alternative to conventional eye drops as it offers longer precorneal residence time and excellent ocular tolerance.

Key words: Carbopol 940 (CB), ophthalmic, gel, hydroxy propyl (HP), methyl cellulose (MC).