International Journal of Medicine and Medical Sciences

International Journal of Medicine and Medical Sciences ISSN: 2167-0404 Vol. 6 (5), pp. 332-339, May, 2016. © International Scholars Journals

Full Length Research Paper

Clinical diagnostic indices of obese patients

*1Obimba, Kelechukwu Clarence, 2Ozougwu, Jevas Chibuike, 3Emejulu Ada A, and 4Ihedimbu, Perpetua Chiamaka

*1,3.4Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri. Nigeria.

2Physiology and Biomedical Research Unit, Department of Biological Sciences, Rhema University, Aba, Abia State, Nigeria.

Corresponding author. E mail: kechrisob@yahoo.com. Tel. 07034851899.

Received 22 April, 2016; Accepted 13 May, 2016; Published 22 May, 2016

Abstract

The aim of the study was to investigate the efficacy of the use of biochemical, hematological, blood pressure and anthropometric indices as diagnostic parameters of obesity. The experimental design was a single factor completely randomized design (CRD). Twenty (20) normal human subjects and thirty (30) obese patients were subjected to systolic (SP) and diastolic (DP) blood pressure, body mass index (BMI), serum glycated albumin (GA), fasting blood sugar (FBS), serum aspartate aminotransferase (AST), serum glycated hemoglobin (HbA1c), serum leptin (L), serum total cholesterol (C) and serum triglyceride (T) tests. Results recorded of the normal human subjects and obese patients, expressed as mean ± standard error (S.E) (unit) were as follows : SP (120.52 ± 9.14) and (146.87 ± 11.23) (mmHg), DP (75.6±1.7) and (90.11±0.9) (mmHg), BMI (15.3±0.7) and (30.5 ±1.7) (kg/m2), GA (15.5±0.2) and (13.1±0.3) (%), FBS (68.8±4.7) and (125.8±1.7) (mg/dl), AST (9.2 ±1.9) and (22.5 ±1.0) (U/l), HbA1c  (6.15 ±0.4) and (8.15 ±0.3) (%), L (10.5 ±1.0) and (31.5 ±1.0) (ng/ml.kg), C (170±1.5) and (195±2.0) (mg/dl), and T (175.51±2.3) and (110.2±0.215) (mg/dl), respectively. The mean values of SP, DP, and BMI, FBS, AST, HbA1c, L, C and T   were significantly higher (p<0.05), but that of GA was significantly lower (p<0.01) in obese patients compared with normal human subjects. The statistical regression and correlation between L (ng/ml.kg) and BMI (kg/m2) of obese patients were significant (p<0.05)(r = 0.963). Incidence of obesity correlated positively and significantly (p<0.05) with significant increase (p<0.05) in BMI, FBS, AST, HbA1c, L, C, T and significant decrease (p<0.01) in GA of the obese patients.  These significant differences/alterations could be used as effective criteria/yardstick for the diagnosis, and management/treatment of obesity or monitoring of recovery from obesity.

Key words: Leptin, glycated albumin, glycated hemoglobin.