African Journal of Parasitology Research
African Journal of Parasitology research ISSN 2343-6549 Vol. 2 (11), pp. 161-165, November, 2015. © International Scholars Journals
Full Length Research Paper
Field evaluation of SD Bioline Malaria Antigen P.f® for Plasmodium falciparum malaria diagnosis in Nanoro, Burkina Faso
*Halidou Tinto1,2, Olivier Sombié1, Innocent Valea1,2, Ferdinand Lankoandé1,Sandrine Yara1, Palpouguini Lompo1, Marc C Tahita1, Adama Kazienga1, Sayouba Ouédraogo1, Hermann Sorgho1, Maaike De Kroop3, Raffaella Ravinetto3,4
1Institut de Recherche en sciences de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Nanoro, Burkina Faso.
2Departement de Recherche Clinique, Centre Muraz, Bobo-Dioulasso, Burkina Faso.
3Clinical Trial Unit, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
4 Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
*Corresponding author: E-mail: email@example.com. Tel: +226 70346354.
Accepted 12 November, 2015
A study was conducted to assess the performance of the SD Bioline Malaria Antigen P.f® compared to the ‘’gold standard’’ microscopy as for the diagnosis of Plasmodium falciparum malaria in Nanoro, Burkina Faso. Microscopy and RDT diagnosis were performed on 254 blood samples. 78.09% (189/242) were positive by microscopy compared to 93.8% (227/242) diagnosed by RDT. The RDT test reported 39 false-positive results and one false-negative result. The RDT showed high sensitivity of 99.47% [IC95%: 98.56-100], with sensitivity increasing with increasing parasite density. RDT specificity was 26.42% [IC95%: 20.86-31.97]. Low specificity limits accuracy for malaria diagnosis. However, in areas of hyperendemic malaria, high sensitivity is preferable to over diagnosis.
Keywords: Malaria, Plasmodium falciparum, Rapid Diagnosis Tests, SD-Bioline Malaria Antigen P.f test, Accuracy.
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