African Journal of Medical Case Reports
African Journal of Medical Case Reports Vol. 2 (2), pp. 022-023, February, 2014. © International Scholars Journals
Cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) in systemic lupus erythematosus: An overlapping syndrome?
El youbi Randa, Mohamed Arrayhani and Tarik sqalli
Department of nephrology at University hospital, Fez, Morocco.
*Corresponding author. E-mail: firstname.lastname@example.org Tel. 00212658932498
Accepted 20 December, 2013
Systemic lupus erythematosus (SLE) and small-sized vessel vasculitis are usually two distinguishable autoimmune diseases. We report a case of novo SLE associated with cytoplasmatic antineutrophil cytoplasmatic antibodies (c-ANCA). A 34-year old woman was admitted to our hospital for purpura, weight loss, inflammatory polyarthralgia and nasal stufﬁness with advanced renal failure. The investigations have revealed positive immunological test (ANN, anti-DNA and c-ANCA). Renal biopsy showed a diffuse proliferative lupus nephritis (class IV-G (A)) with necrotizing crescentic glomerulonephritis. We have retained the diagnosis of SLE associated to c-ANCA. She has received corticosteroids and cyclophosphamide. The evolution was marked by the occurrence of alveolar hemorrhage that caused her death.
Key words: Cytoplasmic anti-neutrophil cytoplasmic antibodies, systemic lupus erythematosus, overlapping syndrome, alveolar hemorrhage, necrotizing crescentic glomerulonephritis.
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