African Journal of AIDS and HIV Research

African Journal of AIDS and HIV Research ISSN 2326-2691 Vol. 5 (4), pp. 250-254, April, 2017. © International Scholars Journals

Full Length Research Paper

In silico analysis of Mycobacterium leprae genome to find out potential drug targets

Asad Amir1, Asif Siddiqui1, Anjali Malik1, Neeraj Tandan2*, Garima Dua1, Garima Rastogi1, Gayatri Sharma1, Richa Goel1 and Singhal Gauvav2.

1Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, Indian.

2Scientific and Applied Research Center, Meerut, Uttar Pradesh, Indian.

*Corresponding author. E-mail: neerajtandan@gmail.com

Accepted 08 April, 2009

Abstract

Mycobacterium leprae is the causative agent of the disease, leprosy. In-silico analysis can be performed on M. leprae genome to find out the potential drug targets. This was done first by database search to find the recorded complete genes with complete sequences of M. leprae and then their comparative study with human by using homology searching using human BLAST. From a total of 1605 genes, potential drug targets have been identified.

Key words: Mycobacterium leprae Genome, BLAST, NCBI, drug target.